Abstract:
Thyroid gland disorders (hypothyroidism) one of the commonest problems
now days in all ages and nationalities, the aim of this study To Asses serum
levels of anti-TPO antibody and thyroid function test parameters (FT4 and
TSH) in positive and negative hypothyroidism in Saudi Arabia.
This was hospital-based cross sectional comparative study, performed in
period from January 2018 to December 2019 in Saudi Arabia. One hundred
and fifty (150) participants, divided into three groups as positive tpo ab
hypothyroidism, negative tpo ab hypothyroidism and healthy individuals,
with different ages and nationalities, blood specimens collected and serum
separated and stored in -20 C till used: TSH and fT4 were measured by
Vitros 5600 and TPO abs by Cobas e 411.
The study results revealed a significant increase in TSH level in positive tpo
hypothyroidism and negative tpo hypothyroidism with p value: 0.00, and
significant decrease in FT4 level in positive tpo hypothyroidism and
negative tpo hypothyroidism with p value 0.00, while TPO abs showed
significant increase in positive tpo hypothyroidism with p value 0.00.There
was no significant correlation between age and positive tpo hypothyroidism
p value 0.274 r=0.158, and no significant correlation between age and
negative tpo hypothyroidism p value 0.808 r=0.035.
In conclusion: this study showed significant increase of TPO in positive tpo
hypothyroidism, with increase levels of TSH in positive tpo hypothyroidism
negative tpo hypothyroidism.
