Assessment of Stimulating Hormone and Free T4 among Positive and Negative Tpo Abs Hypothyroidism among Saudi Arabia Patients

Abstract

Thyroid gland disorders (hypothyroidism) one of the commonest problems now days in all ages and nationalities, the aim of this study To Asses serum levels of anti-TPO antibody and thyroid function test parameters (FT4 and TSH) in positive and negative hypothyroidism in Saudi Arabia. This was hospital-based cross sectional comparative study, performed in period from January 2018 to December 2019 in Saudi Arabia. One hundred and fifty (150) participants, divided into three groups as positive tpo ab hypothyroidism, negative tpo ab hypothyroidism and healthy individuals, with different ages and nationalities, blood specimens collected and serum separated and stored in -20 C till used: TSH and fT4 were measured by Vitros 5600 and TPO abs by Cobas e 411. The study results revealed a significant increase in TSH level in positive tpo hypothyroidism and negative tpo hypothyroidism with p value: 0.00, and significant decrease in FT4 level in positive tpo hypothyroidism and negative tpo hypothyroidism with p value 0.00, while TPO abs showed significant increase in positive tpo hypothyroidism with p value 0.00.There was no significant correlation between age and positive tpo hypothyroidism p value 0.274 r=0.158, and no significant correlation between age and negative tpo hypothyroidism p value 0.808 r=0.035. In conclusion: this study showed significant increase of TPO in positive tpo hypothyroidism, with increase levels of TSH in positive tpo hypothyroidism negative tpo hypothyroidism.