Abstract:
The objective of this study was to investigate the effect of guru on drug metabolizing enzymes in rats. Guru at a dose of 100mg/kg administered orally to rats caused induction of hepatic microsmal mixed function oxidase , but at the dose of 200 and 400 mg/kg inhibited the drug metabolizing enzymes compared to controls that were given rat diet . It is concluded that guru may produce pharmacological effects at the dose of 100mg/kg and toxicological effects at higher doses.
