Abstract:
The objective of the study was to evaluate the efficacy of sulphadimidine, gentamicin, oxytetracycline and their combination in Nubian goats experimentally infected with Trypanosoma evansi. Eleven groups (1-11) were used each of three. Sulphadimidine was given at single i/m dose of (100, 200 and 400 mg/kg). Gentamicin were given at (2, 4 and 8 mg/kg), while oxytetracycline long acting was given at (20 mg/kg). Combinations of sulphadimidine and gentamicin at (200 + 4) and (400 + 8) mg/kg respectively, combinations of sulphadimidine and oxytetracycline (200 + 20) and gentamicin and oxytetracycline (4 + 20) mg/kg respectively were also tested. Sulphadimidine, gentamicin and oxytetracycline at single doses of (200, 400), (4, 8) and 20 mg/kg respectively were succeeded to eliminate the parasite from the peripheral blood at (4), (8 and 7) and (4) weeks post infection respectively. Doses of sulphadimidine and gentamicin at 100 and 2 mg/kg respectively failed to eliminate the parasite from the peripheral blood and the animals were slaughtered at weeks 4 post infection in moribund condition. No significant changes were observed in clinical and haematological parameters of the tested groups. Significant decrease (p≤0.05) in the serum glucose concentration and significant increase (p≤0.05) in the serum urea concentration and in the activity of GOT of the tested groups.
