The Efficacy of Sulphadimidine, Gentamicin, Oxytetracycline and their Combination in Nubian Goats Experimentally Infected with Trypanosoma evansi

Abstract

The objective of the study was to evaluate the efficacy of sulphadimidine, gentamicin, oxytetracycline and their combination in Nubian goats experimentally infected with Trypanosoma evansi. Eleven groups (1-11) were used each of three. Sulphadimidine was given at single i/m dose of (100, 200 and 400 mg/kg). Gentamicin were given at (2, 4 and 8 mg/kg), while oxytetracycline long acting was given at (20 mg/kg). Combinations of sulphadimidine and gentamicin at (200 + 4) and (400 + 8) mg/kg respectively, combinations of sulphadimidine and oxytetracycline (200 + 20) and gentamicin and oxytetracycline (4 + 20) mg/kg respectively were also tested. Sulphadimidine, gentamicin and oxytetracycline at single doses of (200, 400), (4, 8) and 20 mg/kg respectively were succeeded to eliminate the parasite from the peripheral blood at (4), (8 and 7) and (4) weeks post infection respectively. Doses of sulphadimidine and gentamicin at 100 and 2 mg/kg respectively failed to eliminate the parasite from the peripheral blood and the animals were slaughtered at weeks 4 post infection in moribund condition. No significant changes were observed in clinical and haematological parameters of the tested groups. Significant decrease (p≤0.05) in the serum glucose concentration and significant increase (p≤0.05) in the serum urea concentration and in the activity of GOT of the tested groups.