Effects of Guru (Cola nitida) on Drug Metabolizing Enzymes in Rats

Please use this identifier to cite or link to this item: https://repository.sustech.edu/handle/123456789/16863

Title:	Effects of Guru (Cola nitida) on Drug Metabolizing Enzymes in Rats
Authors:	Ahmed , A.M. Mohamed , O. S. A. Homeida , Mohamed .A.M.
Keywords:	Aminopyrine-N-demethylase , Aniline-4-hydroxylase, UDP-glucuronyltransferase Glutathione-S-tranferase, Cytochrome p-450
Issue Date:	2012
Publisher:	Sudan University of Science and Technology
Citation:	Ahmed , A.M. . Effects of Guru (Cola nitida) on Drug Metabolizing Enzymes in Rats / A.M. Ahmed , O. S. A. Mohamed , Mohamed .A.M. Homeida .- Journal of Science and Technology .- vol 13 , no 2 .- 2012 .- article .
Abstract:	The objective of this study was to investigate the effect of guru on drug metabolizing enzymes in rats. Guru at a dose of 100mg/kg administered orally to rats caused induction of hepatic microsmal mixed function oxidase , but at the dose of 200 and 400 mg/kg inhibited the drug metabolizing enzymes compared to controls that were given rat diet . It is concluded that guru may produce pharmacological effects at the dose of 100mg/kg and toxicological effects at higher doses.
Description:	article
URI:	http://repository.sustech.edu/handle/123456789/16863
ISSN:	ISSN 1605-427X
Appears in Collections:	Volume 13 No. 2

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