Abstract:
Asthma is a chronic inflammatory disease of airways and it is a very
common disease with immense social impact. The treatment of asthma
affects the concentration of plasma urea and creatinine.
This is descriptive analytical study conducted during the period from the
February to July 2014to evaluate plasma concentration of urea and
creatinine in asthmatic patients under steroid therapy, included 30 patients
with hypertensive and non-hypertensive Asthmatic patients as case group,
and 20 healthy individual as control group. Samples were collected to
measure the concentration of urea and creatinine by using colorimetric
methods. The data analyzed by SPSS program.
The result found significant increase in the mean of creatinine between
asthmatic patients and non-asthmatics (P-value = 0.001), and no significant
difference between mean of urea in case and control (P-value = 0.06). Also
there is no significant difference between mean of creatinine and urea in
hypertensive and non-hypertensive asthmatic patients (P-value = 0.198,
0.797) respectively.
This study shows that there is significant negative moderate correlation
between creatinine and concentration treatment duration and insignificant
weak negative correlation between urea and concentration treatment
duration.
The present study showed that the asthma treatment has effect on creatinine
concentration with the duration of treatment resulting in lowering creatinine
concentration, and no effect on urea concentration.
