Abstract:
The lack of anatomical details in standard 131 iodine whole body scanning
(1311 WBS) interferes with the proper localization of metastatic
differentiated thyroid carcinoma (DTC) lesions. In addition, nearby or
overlapping variable physiological distribution of 1311 may affect the
specificity of 1311 uptake, giving indeterminate results. The aim of this study
was to demonstrate the clinical usefulness of simultaneous co-registration
of 99m Tc MDP bone scanning as an anatomical landmark with 1311
scanning in the evaluation of metastatic DTC.
Material and Methods:
Twenty-five patients (16 females and 9 males, mean age + SD = 52 + 13
years) with metastatic DTC (17 papillary, 8 follicular), were included. Whole
body scanning were obtained 48 hours after oral administration of 185-370
v
MBq 1311 and 2 hours after IV administration of 185-370 MBq 99 mTc MDP.
Occasionally, additional simultaneous co-registration of localized detailed
images was also performed. The two planar images were fused with
optional fusion of SPECT images. Fusion image were considered to improve
image interpretation in comparison with standard 1311 scanning when they
provided better localization of lesion.
