Abstract:
Introduction: Immunosuppressive drug therapies used to prevent transplant rejection
but predisposes the recipient to infections and malignancies. they have effects on
various tissues of the body including the cells of oral mucosa.
Objectives: To demonstrate the cytomorphological changes in buccal mucosa among
Sudanese renal transplantation recipients.
Materials and methods This is a cross sectional descriptive study conducted at
Khartoum state , the cytological samples were collected from renal transplant
recipient attending Sudanese Kidney Transplanted Association Hospital in Khartoum
state, during the period between May to December 2011. One hundred renal
transplant recipients patients approached to participate in this study. Oral scraped
samples were smeared on microscopical slide and stained with Papanicolaou stain.
Results: The cytological finding of the patient smears showed that, 35 (35%), 34
(34%), 14 (14%), 10(10%) and 7(7%) as no changes, non specific inflammation
changes, fungal infection changes, viral infection changes, and dyskaryotic cells
respectively.
Discussion: The statistical analysis showed insignificant association between different
variable and cytological changes. This result is supported with studies from different
countries.
Conclusion and recommendation: There were morphological alterations in oral
epithelial cells in kidney transplant patients. This may be related to the
immunosuppressive agents. Further studies are needed to confirm this finding with
larger sample size.
