Abstract:
A cross- sectiona comparative study, conducted during the period from
January to July 2010, compared the plasma levels of magnesium, triglycerides
and total cholesterol of 60 Sudanese patients suffering from type2 diabetes
mellitus as a diabetic test group; 30 of them were controlled diabetics (test
group A) and 30 were uncontrolled diabetics (test group B) in addition to 30
apparently healthy volunteers as a control group. All Participants in this study
were from Khartoum State. The test groups (A&B) and the control group were
matched for age. The levels of the plasma magnesium, triglycerides and total
cholesterol
were
determined
in
fasting
blood
samples
using
a
spectrophotometer and reagents from Biosystem company.
The means of the plasma levels of total cholesterol and triglycerides
were significantly raised but the mean of the magnesium levels was
significantly reduced in both of the test groups (A&B) when compared to the
control group (P.Value <0.05).
In reference to control of diabetes, the mean of the plasma
levels of magnesium was significantly reduced in the test group (B)
when compared to the test group (A) (P.Value = 0.00), whereas the two
groups, showed no significant difference between the means of plasma
triglycerides but the mean of total cholesterol was significantly raised in
the test group (B) compared to test group (A)
In the diabetic test group (n= 60) the plasma levels of magnesium
showed a significantly weak negative correlation, While total cholesterol and
triglycerides showed insignificant week positive correlation with the duration
of diabetes mellitus. The test group showed a significant weak negative
correlation between the plasma total cholesterol and triglycerides with the
plasma levels of magnesium and that of total cholesterol and triglycerides.
From the results of the present study it is concluded that: in
Sudanese patients with type2 diabetes mellitus, the plasma levels of
magnesium are reduced, whereas that of total cholesterol and triglycerides
are raised. Uncontrolled diabetics are at a higher risk of hypomagnesaemia
and Hyperlipidemia compared to controlled diabetics.