Abstract:
A prospective , case – control study conducted during the period
from May to October 2007 ,compared serum levels of α-amylase and
creatine kinase enzymes of 50 patients with long standing type 2
diabetes mellitus ( >10 years) with 30 apparently healthy individuals
( non diabetic) as a control group.
Both the test group and the control group were selected randomly
from Jabber AbuEliss diabetes center in Khartoum and Bahri diabetes
center.
In this study, the mean of the serum levels of α- amylase was
significantly reduced in the diabetic group compared with that of the
control group (P<0.05) and there was no correlation between the
serum levels of α- amylase and the duration of the diabetes mellitus (r
=0.00). Reduction of the levels of α- amylase could be due to
insufficiency of exocrine pancreas.
In this study the mean of the levels of serum creatine kinase was
significantly elevated in the diabetic group when compared with that
of the control group. (P <0.05) and there was a weak positive
correlation between the serum creatine kinase and the duration of the
diabetes mellitus (r = 0.40).
From this study it was concluded that; reduction of the serum levels
of α- amylase could be part of the exocrine pancreatic insufficiency,
and the increase of the serum levels creatine kinase may be due to
damage of cardiac muscles or skeletal muscles, so study of creatine
kinase isoenzymes is important for differentiation.
