Abstract:
IL-10 is a molecule with immune-regulatory properties, secretion of it in sepsis could limit and ultimately terminate inflammatory responses , which called as anti-inflammation cytokine.
This is a case-control study that aimed to evaluate the IL-10 level in neonatal sepsis cases and in neonates control subjects in Khartoum state during the period from June 2020 to May 2021 .
Fifty two subjects, selected randomly in this study, with age varies from 1- 13 day, 26 subject were septic neonates (13 males ,and 13 females) ,26 were healthy neonates (13 males and 13 females ).
Venous blood sample (1ml) was collected in EDTA container from each subject.
IL-10 concentration was measured using Enzyme Linked Immunosorbent Assay (ELISA) in lab of Institute of Endemic Diseases. The data was analyzed using Statistical Package Social Science programme (Version 20). independent sample t-test was used to compare between means. P. value significant when ≤0.05.
It was found the mean of IL-10 were 117.9±117 and 10.66±6.7 in the case group and control group respectively . IL-10 level was significantly elevated in neonatal sepsis than the control group ( P. value 0.000 ). The difference in mean of IL-10 between males and females in the case group of this study was not statistically significant (P. value 0.952). There was no statistical correlation between IL-10 level and age ,and IL-10 level and weight in study group ( P. value 0.391 , 0.291) respectively .
There was no statistical correlation between level of IL-10 and duration (early / late) of sepsis ( p. value 0.993) ,And level of IL-10 between term and pre term neonates (p. value 0.320).
The study concluded that in the studied population, IL-10 concentration may be useful as prognostic marker for neonatal sepsis.
