Abstract:
This is descriptive retrospective study conducted at International Medical Center in Jeddah, Saudi Arabia. From September 2019 to January 2020. The study aimed to detect CK20& CD15 expression in Gallbladder tumors, using immunohistochemistry staining technique. Samples were collected from51 patients previously diagnosed as bladder tumors, 16 (31.3%) were benign and 35 were malignant (68.7%). their age ranges from 25 to 97 years with mean age of 60 years. (26) of them were females with percentage (51%) and 25 patients were males with a percentage (49%).
The benign tumors samples 16 with percentage (31.3%) show negative result with CK20 & CD15.
CK20 was positive in 31 (60.8%) samples and negative in 20 (39.2%) samples.
Positive results in 13 samples of Adenocarcinoma with percentage (37.1%) and 18 in Transitional Cell Carcinoma with percentage (51.4%).CK20 was negative in 4 samples with percentage (11.5%). There is a significant correlation of CK20 & malignant gallbladder tumors (P-value=0.000)
CD15 was positive in 9 samples with percentage (17.6%) and negative in 42 samples with percentage (82.4%), all the positive CD15 results were in Transitional Cell carcinoma.
There is a significance correlation between CD15 expression and malignant tumors of gallbladder (P-value= 0.000).
