Abstract:
Kidney failure occurs when the kidneys partly or completely lose their
ability to carry out normal functions. Osteomalacia may be part of the
spectrum of osseous abnormalities that can be observed in patients with
chronic renal insufficiency. Osteomalacia is characterized by incomplete
mineralization of normal osteoid tissue. This condition is termed by renal
osteodystrophy.
The aim of this study was to evaluate the association of chronic renal
failure and osteomalacia in adult Sudanese patients who attending
Khartoum Teaching Hospital, renal dialysis unit.
This is a cross-sectional descriptive and analytical study conducted at
Khartoum Teaching Hospital during the period of first of February 2010
to the first of May 2010. This study included both sexes: 30 males (75%)
and 10 females (25%).
2.5 ml of venous blood was bleed in lithium heparin container and
investigated for calcium level and ALP activity. Semi automated
spectrophotometer (micro lab 300) was used for the calcium and ALP
enzyme measurement.
The results of all patients showed that calcium levels were slightly
decreased (mean value was 7.66 ± 1.38 mg/dl) than normal mean value
(8.5 – 10.5 mg/dl), but this reduction was statistically insignificant (p
value 0.8), while ALP activity results were slightly increased (295.93 ±
206.68 u/l) than normal mean value (90 – 270 u/l), this increase was
statistically significant (p value 0.04).
In conclusion: The results indicated that there was statistically significant
relationship between the chronic renal failure and osteomalacia
(P value < 0.05).