Abstract:
This study was conducted to measure plasma levels of s( AST, ALT, ALP) liver enzyme in patients with b tuberculosis in Khartoum state . Fifty samples were collected from patients during the period between April to May 2017 , from randomly chosen patients diagnosed with pulmonary tuberculosis un
der taking the treatment for 2 months from Alshaab teaching hospital and fifty apparently healthy individuals serve as control group.
Cobas integra 400 plus was used to estimate plasma levels of ( AST, computer program .
The study results showed that , plasma levels of AST , ALP were significantly increased in patients group compared to control group (mean ± SD for cases versus control for (AST,ALP) : (32.04 ± 18.15 IU\L ,p-value =0.00) (141.02 ± 145.20 IU\L , p-value =0.00) respectively .
The results of this study showed that , there were significantly increased in the levels of plasma AST , ALT , ALP in male patients compared to female (mean ± SD) for male versus female (43.28 ± 19.47 versus 20.80 ± 5.51 IU\L p-value =0.00) , (28.80 ± 21.55 versus 15.61 ± 9.10 IU\L p-value =0.01) and (181.08 ± 194.30 versus 99.96 ± 42.19 IU\L p-value =0.05) respectively .
The results of this study showed that , there was significant decrease in the mean of BMI in patients with pulmonary tuberculosis compared to control group (mean ± SD for case versus control (0.17 ± 18.68 ) versus (21.54 ± 1.72 ), p-value = 0.04) .
common among age between (19-49) years 70% and 30% of patients between age (50-82) years , this disease most abundant in male (60%) than female (40%) .
Person correlation showed no correlation between plasma levels of AST , ALP and age (r = 0.15, p-value =0.30) (r = 0.18 , p-value = 0.77) respectively .
Person correlation showed a significant weak negative correlation between plasma level of ALT and age (r = -0.18 , p-value = 0.05).
In conclusion : the plasma levels of AST , ALP were significantly increased and there was insignificant difference in ALT in patients with pulmonary tuberculosis under taking the treatment for 2 months in Khartoum state .
