Abstract:
This is a case- control study aimed to measure serum iron and total iron binding capacity (TIBC) in Sudanese females newly diagnosed with breast cancer in the Radio Isotope Center Khartoum (RICK) and apparently healthy Sudanese females.
Venous blood samples were collected from 50 females with breast cancer referred to RICK and 70 samples from apparently healthy females as control group from attendants of Primary Health Centers in Khartoum State. Case and control groups were matched for age group and parity.
Measurement of serum iron and TIBC was performed by using manual method (IRON-FERROZINE) and transferrin saturation percent was calculated after measurement of serum iron and TIBC. The collected data were analyzed by SPSS computer program (IBM SPSS version 22.0).
The mean age ± SD in case group was 47.0 ± 12.7 years and 42.0 ± 13.0 years in control group, mean of parity number ± SD was 4.0 ± 3.8 times in case and control groups in married females.
The result showed that the mean of serum iron ± SD in case group was 244.30 (µg/dL) ± 151.598 and in control group was 57.59 (µg/dL) ± 43.191 (P.value = 0.000).
Mean of TIBC ± SD in case group was 412.98 (µg/dL) ± 177.460 and in control group it was 403.71 (µg/dL) ± 168.765 (P. value = 0.838).
Mean of transferrin saturation percent ± SD in case group was 61.08 % ±41.523 and in control group was 223.23 % ±149.195 (P.value=0.000).
This study concluded that there is a significant difference in serum iron and transferring saturation percent between Sudanese females newly diagnosed with breast cancer and apparently healthy females.
Statistically, there is no significant difference in serum iron, transferring saturation percent with regard to type of breast cancer, histopathological grade, or menopausal status.
There is significant difference in mean of TIBC according to histopathological grade and there is no significant difference according to type of breast cancer.
