Abstract:
Iron compound drugs (ferrous sulphate tablets, ferrous gluconate tablets and ferric hydroxide poly maltose syrup) have been chosen to follow up the changes in concentration of iron during storage in different conditions (00C, Sun light, 600C), for certain periods. The study was carried out by titration with cerium sulphate, atomic absorption and infra red spectroscopy methods.
Titration of cerium sulphate showed that the percentage of iron(II) in ferrous sulphate tablet at room temperature is 20.083%. There are no changes after 3, 10 and 15 days of storage at 00C , a continuous decrease in concentration occurred after storage for 10and 25 days at sun light where the percentage dropped to 19.6% and 19.04% respectively. Few significant changes after storage for 15 and 25 days at 60oC were observed.
The percentage of iron(II) in ferrous gluconate tablet at room temperature is 5.559%. No change in concentration was observed after 3, 10 and 15 days storage at 0oC. Then a continuous decrease occurred after storage for 10,20 and 30 days at sun light where the percentage was 5.551% ,5.53% and 5.17% respectively. Few significant changes were detected after storage for 10, 15 and 25 days at 60oC.
In ferric hydroxide poly maltose syrup, iron was quantified by atomic absorption. The quantity of iron(III) in 1ml of ferric hydroxide poly maltose syrup was 8.582mg and there are no changes in quantity after storage at 00C, sun light and 600C for 30 days.
