Abstract:
Synthesis of some 1-amino-5-acetyl-6-methyl-4-aryl-3,4-dihydropyrimidine -2-
thione and 1-amino arylmethylidiene -5- acetyl -6- methyl -4-aryl-3,4-
dihydropyrimidine-2-thione, from reaction of acetyl acetone, thiosemicarbazide
and aldehyde was achieved. Synthesis of some 1-amino-5-ethoxycarbonyl-6-
methyl-4-aryl-3,4-dihydropyrimidine-2-thione and 1-amino arylmethylidiene-5-
ethoxycarbonyl -6-methyl- 4-aryl- 3,4-dihydropyrimidine-2-thione was
accomplished by reaction of ethyl acetoacetate, thiosemicarbazide and aldehyde.
The reaction was carried out in presence of ZnCl2 as catalyst. Synthesis of 5-
acetyl-6-methyl-4-aryl-3,4-dihydropyrimidine-2-one, 5-acetyl-6-methyl-4-aryl-3,4-
dihydropyrimidine-2-thione, 5-ethoxycarbonyl-6-methyl -4- aryl -3,4- dihydro
pyrimidine-2-one and 5- ethoxycarbonyl-6-methyl-4-aryl-3,4- dihydro pyrimidine-
2-thione the reaction was accomplished without catalyst. The reaction progress was
followed by TLC analysis and the chemical structure confirmed by spectroscopic
analysis (UV, IR, ¹HNMR, ¹³CNMR and MS)
