Abstract:
The morphological difference in mean platelet volume (MPV) and platelet distribution width (PDW) of platelet imply assessing the function of platelets. MPV and PDW generally reported high in uncontrolled type 2 diabetes mellitus patients.
This study is a hospital-based non-intervention analytical case-control study aimed to determine and compare MPV and PDW in uncontrolled type 2 diabetes mellitus patients in comparison with non-diabetic individuals among Sudanese during the period from January to July 2019.
Three ml of EDTA anticoagulated blood was taken from 200 participants who selected conviniously (100 are type 2 diabetic patients with uncontrolled glycemic status (HbA1c> 7%) as cases and 100 healthy non-diabetic individuals (HbA1c between 4.0%–5.6%) as controls). MPV and PDW measured by the automated hematological analyzer (CBC Sysmex XP-300). The data obtained was analyzed by the SPSS computer program.
The mean age of uncontrolled type 2 diabetes mellitus patients was (57.05±14.262) years and in the non-diabetic individuals was (50.42±13.723) years. The percentage of gender in uncontrolled type 2 diabetes mellitus patient’s male was (41%), and female was (59%), and in non-diabetic individual’s male was (49%), and female was (51%). The mean of HbA1c in uncontrolled type 2 diabetes mellitus patients was (9.433±2.0113%), and in the non-diabetic individuals was (5.106 ±0.4000%) with a statistically significant difference between cases and controls (P.value= 0.000). The mean of MPV in uncontrolled type 2 diabetes mellitus patients was (10.067±1.2100fl), and in the non-diabetic individual was (9.966±1.1328fl) with a statistically insignificant difference between cases and controls (P.value= 0.543). The PDW in uncontrolled type 2 diabetes mellitus patients was (12.857±2.4368fl), and in the non-diabetic individuals was (12.725±2.2530fl) with a statistically insignificant difference between cases and controls (P.value=0.689). In cases the correlation between HbA1c and PDW showed strong positive correlation (P.value= 0.028, r=0.781), and showed no correlation between HbA1c and MPV (P.value=0.182, r=0.135).
In conclusion, PDW and MPV are not affected by uncontrolled type 2 diabetes mellitus. There is a strong positive correlation between HbA1c and PDW and no correlation between HbA1c and MPV among uncontrolled type 2 diabetes mellitus patients.
