Measurement of Mean Platelet Volume and Platelet Distribution Width among Uncontrolled Type 2 Diabetic Sudanese Patients

Abstract

The morphological difference in mean platelet volume (MPV) and platelet distribution width (PDW) of platelet imply assessing the function of platelets. MPV and PDW generally reported high in uncontrolled type 2 diabetes mellitus patients. This study is a hospital-based non-intervention analytical case-control study aimed to determine and compare MPV and PDW in uncontrolled type 2 diabetes mellitus patients in comparison with non-diabetic individuals among Sudanese during the period from January to July 2019. Three ml of EDTA anticoagulated blood was taken from 200 participants who selected conviniously (100 are type 2 diabetic patients with uncontrolled glycemic status (HbA1c> 7%) as cases and 100 healthy non-diabetic individuals (HbA1c between 4.0%–5.6%) as controls). MPV and PDW measured by the automated hematological analyzer (CBC Sysmex XP-300). The data obtained was analyzed by the SPSS computer program. The mean age of uncontrolled type 2 diabetes mellitus patients was (57.05±14.262) years and in the non-diabetic individuals was (50.42±13.723) years. The percentage of gender in uncontrolled type 2 diabetes mellitus patient’s male was (41%), and female was (59%), and in non-diabetic individual’s male was (49%), and female was (51%). The mean of HbA1c in uncontrolled type 2 diabetes mellitus patients was (9.433±2.0113%), and in the non-diabetic individuals was (5.106 ±0.4000%) with a statistically significant difference between cases and controls (P.value= 0.000). The mean of MPV in uncontrolled type 2 diabetes mellitus patients was (10.067±1.2100fl), and in the non-diabetic individual was (9.966±1.1328fl) with a statistically insignificant difference between cases and controls (P.value= 0.543). The PDW in uncontrolled type 2 diabetes mellitus patients was (12.857±2.4368fl), and in the non-diabetic individuals was (12.725±2.2530fl) with a statistically insignificant difference between cases and controls (P.value=0.689). In cases the correlation between HbA1c and PDW showed strong positive correlation (P.value= 0.028, r=0.781), and showed no correlation between HbA1c and MPV (P.value=0.182, r=0.135). In conclusion, PDW and MPV are not affected by uncontrolled type 2 diabetes mellitus. There is a strong positive correlation between HbA1c and PDW and no correlation between HbA1c and MPV among uncontrolled type 2 diabetes mellitus patients.