Abstract:
Osteoporosis is a highly prevalent public health problem with osteoporosisrelated
fractures that account for high morbidity and mortality.
The study compared the plasma level of Alkaline phosphatase, calcium and
phosphorous of 50 women with osteoporosis as test group and 50 apparently
healthy women as control group and it is case control study carried out in a
period from March to December 2018 in Khartoum state, Sudan.
Venous blood (3ml) was collected from the participants in heparin containers
and gently mixed. The plasma level of alkaline phosphatase, calcium and
phosphorous measured by spectrophotometer using commercial reagent kits
from Biosystem Company.
The obtained data were analyzed by both Student's Independent T test and
person correlation test using SPSS version 16 computer program.
By analysis of the result, both control and osteoporosis cases had ALP and
calcium within normal range, however the difference between the levels was
significantly lower in osteoporotic (63.38±20.35) and(7.31±2.28)mg/dl
phosphorus was significantly higher in osteoporosis (4.46±1.12) in comparison
to the control group (4.00±1.08) yet their values are still within normal range
Also found there is a weak positive correlation between the ALP and the BMI
with r = (0.3), but no correlation between the calcium, phosphorus with BMI in
case group.
From the result of this study, it is concluded that: Osteoporosis is associated
with low plasma level of ALP and calcium, where associate with high level of
the phosphorus.
Also there is no correlation between the test parameters and age and the BMI of
the cases group and there is a weak positive correlation between the ALP and
BMI.
