Evaluation of Plasma Alkaline Phosphatase, Calcium and Phosphorous in Post-menopausal Women with Osteoporosis

Abstract

Osteoporosis is a highly prevalent public health problem with osteoporosisrelated fractures that account for high morbidity and mortality. The study compared the plasma level of Alkaline phosphatase, calcium and phosphorous of 50 women with osteoporosis as test group and 50 apparently healthy women as control group and it is case control study carried out in a period from March to December 2018 in Khartoum state, Sudan. Venous blood (3ml) was collected from the participants in heparin containers and gently mixed. The plasma level of alkaline phosphatase, calcium and phosphorous measured by spectrophotometer using commercial reagent kits from Biosystem Company. The obtained data were analyzed by both Student's Independent T test and person correlation test using SPSS version 16 computer program. By analysis of the result, both control and osteoporosis cases had ALP and calcium within normal range, however the difference between the levels was significantly lower in osteoporotic (63.38±20.35) and(7.31±2.28)mg/dl phosphorus was significantly higher in osteoporosis (4.46±1.12) in comparison to the control group (4.00±1.08) yet their values are still within normal range Also found there is a weak positive correlation between the ALP and the BMI with r = (0.3), but no correlation between the calcium, phosphorus with BMI in case group. From the result of this study, it is concluded that: Osteoporosis is associated with low plasma level of ALP and calcium, where associate with high level of the phosphorus. Also there is no correlation between the test parameters and age and the BMI of the cases group and there is a weak positive correlation between the ALP and BMI.