Measurement of Some Hematological Parameter in Chronic Myeloid Leukemia Patients in Radiation and Isotope Center – Khartoum 2012

Abstract

This is descriptive cross sectional hospital study was carried out in radiation and isotope center Khartoum (RICK )from April to June 2012, To measure the complete blood count (CBC) in patients with chronic myeloid leukemia. Sixty patients of both gender were informed about the study expected out come and agreement of participation was obtained. In additive forty healthy people were selected as a control group. A structured questionnaire was used to collect information about patient age, sex, tribe, patient history of disease. Three ml of venous blood was collected in EDTA anti coagulant container from all patients and controls .Automated hematological analyzer (Sysmex KXN-21 ) was used to measure Complete Blood Count . Differential leukocyte count was estimate manually. Statistical package for social science (SPSS) computer program was used for data analysis. The results at hemoglobin level (mean 10.2±1.8 g\dl ) , hematocrit (mean 31.3±6.8 %) and RBC`s count (mean3.5+0. ×91012 \L) of patients significant decrease with (p. value ٠ .00) when campered with control while Total white blood cell count(maen 110.8±8. 4×109 \L ) and Platelets count (mean 543±44. ×8109 \L) were significantly increased (p.value 0.00 and 0.02 respectively) . The differential leukocyte count of patient group show significant increase in the mean of neutrophil , esionphil, basophil, stab, metamylocyte, mylocyte, promylocyte, myloblast and nucleated red blood cell compared to that of control . But lymphocyte(11.9 ±10.6) show significantly decreased while monocyet (5 .1±4.0) insignificantly increased . The study show that the differential leukocyte count of Ph +ve CML patients was insignificantly increased in basophile ( mean 4.9±3.7), but monocyet (mean11.3 ±10.6) was insignificantly decreased when campered with of Ph -ve CML patients.