Cytomorphological Changes in Buccal Mucosa Among Sudanese Renal Transplantation Recipients

Abstract

Introduction: Immunosuppressive drug therapies used to prevent transplant rejection but predisposes the recipient to infections and malignancies. they have effects on various tissues of the body including the cells of oral mucosa. Objectives: To demonstrate the cytomorphological changes in buccal mucosa among Sudanese renal transplantation recipients. Materials and methods This is a cross sectional descriptive study conducted at Khartoum state , the cytological samples were collected from renal transplant recipient attending Sudanese Kidney Transplanted Association Hospital in Khartoum state, during the period between May to December 2011. One hundred renal transplant recipients patients approached to participate in this study. Oral scraped samples were smeared on microscopical slide and stained with Papanicolaou stain. Results: The cytological finding of the patient smears showed that, 35 (35%), 34 (34%), 14 (14%), 10(10%) and 7(7%) as no changes, non specific inflammation changes, fungal infection changes, viral infection changes, and dyskaryotic cells respectively. Discussion: The statistical analysis showed insignificant association between different variable and cytological changes. This result is supported with studies from different countries. Conclusion and recommendation: There were morphological alterations in oral epithelial cells in kidney transplant patients. This may be related to the immunosuppressive agents. Further studies are needed to confirm this finding with larger sample size.