DETERMINATION OF PLASMA LIPID PROFILE IN CHILDREN WITH NEPHROTIC SYNDROME ASTUDY IN KHARTOUM-SUDAN

Abstract

This study was conducted during May 2001- March 2002 to evaluate the lipid profile level (Total cholesterol, Triglycerides, LDL low density lipoprotein cholesterol , HDL high density lipoprotein cholesterol ) in the blood plasma and plasma albumin . of children with nephrotic syndrome . Forty children (<15 years) affected by nephrotic syndrome were selected from four different hospitals in Khartoum state (Soba hospital, Khartoum Children Hospital , Ahmed Gasim Children Hospital and Omdurman Children Hospital) and were compared with 20 healthy children as control group .( The level of plasma lipids, lipoprotein and albumin were measured by colorimetric method). The mean plasma total cholesterol , ( cholesterol , trglycerides LDL iow density lipoprotein cholesterol , HDL high density lipoprotein cholesterol) were (269 + 50) , (170 +58) , 179 + 47) and ( 58 + 20 ) mg /dl, respectively in the patients group compared to the mean (108 + 15) , (56 + 19) , (37 + 17 ) , (40 +13) mg /dl in the control group(P<0.0001) This study indicate downward (─ve) the correlation between plasma albumin level and plasma lipids level (total cholesterol , triglycerides , LDL low density lipoprotein cholesterol, HDL high density lipoprotein cholesterol ) in patients group .