Evaluation of Haemostatic Mechanism in Sudanese Pregnant Women Attending Khartoum Teaching Hospital Clinic

Abstract

This is a cross-sectional descriptive and analytical study, conducted at Khartoum Teaching Hospital during the period from February to June 2011.The aim of this study was to assess the haemostatic parameters (Platelets count, Prothrombin time (PT); International normalized ratio (INR), activated partial thromboplastine time (A PTT) and Fibrinogen level) in healthy Sudanese pregnant women who attended Khartoum Teaching Hospital (obstetric ward).One hundred and thirty samples (130) were collected from hundred (100) Sudanese pregnant women, and thirty (30) non pregnant women (control). The participants were informed about the study and agreed for participation. The study population was divided into three groups according to month of pregnancy : first,second and third trimester .Five ml of venous blood were taken from each subject 2.5 ml in EDTA containers for platelets count ,and 2.5 ml in tri sodium citrate containers these were tested for PT, INR, APTT and fibrinogen level..Fully automated hematological analyzer (Sysmex Kx 21 N was used for platelets count and Sysmex CA500 was used for analyzing PT, INR, APTT and fibrinogen level). Statistical analysis showed significant decrease in platelet count mean during pregnancy (225×103/μL) compared with control (329×103/μL) p.value (<0.05).Significant decrease (p.value <0.05)was noted between the APTT mean of pregnant women(30.7 seconds) and the APTT mean of non pregnant women(34.0 seconds)and there was also significant mild decrease in PT mean (14.7) with INR( 1.2) during pregnancy compared to control(15.5 sec) with INR(1.3) p.value(<0.05).The study was also showed that there was a significant increase in plasma fibrinogen level in pregnant women when compared with non pregnant women (mean of pregnant fibrinogen(4.3g/l),non pregnant mean(2.5g/l)with p.value(<0.05) and there was a positive correlation between number of pregnancies before and the level of fibrinogen.