Estimation of Creatine Kinase Level in Patients with Hypothyroidism

Abstract

This descriptive case control study of 60 subjects were conducted to Khartoum Atomic Energy Hospital Laboratory. Measurement of thyroid hormones and the enzyme creatine kinase were determined in (20) control subject which were not suffering from any disease, specially hypothyroidism, with random distribution of age and sex during the period May – December 2001. also Measurements were determined in (40) subjects with hypothyroidism. Thyroid hormones, triiodothyronine (T3), tetraiodothyronine (T4) and thyroid stimulating hormone (TSH), also age and sex was determined then the catalytic activity of creatine kinase were measured for control and hypothyroidism subject. Measurements obtained in this study revealed that creatine kinase enzyme of the hypothyroidism subjects (40) was significantly elevated than the levels of the control subjects (20). This was indicated that hypothyroidism causes elevation to the total catalytic activity of creatine kinase (CK). This study appeared that depending on the degree of hormones deficiency (T3, T4 & TSH), skeletal muscle involvement occurs on hypothyroidism. Further studies may explain the abnormalities in the skeletal muscles function in hypothyroidism subject and time caused of recovery in these abnormalities after treatment by thyroid hormone administration.