Red Blood Cell Indices and Morphology among Patients with Thyroid Diseases in Khartoum State

Abstract

Macrocytic anemia can develop infrequently in patients with thyroid disease mainly hypothyroidism and has high mortality rate. hypothyroidism –induced Macrocytic anemia is a serious problem that affect patients treatment . The objective of this study is the detection of changes in hematological parameters (mean cell volume, mean cell hemoglobin) among Sudanese patients with thyroid disease attending certain Khartoum clinical centers. A descriptive cross – sectional hospital-based study was conducted from (March 2013 to August 2013). 100 blood samples were taken from Sudanese thyroid disease patients (59 patients were hyperthyroidism and 41 patients were hypothyroidism) in police hospital and East Nile hospital and 50 blood samples from healthy volunteers as controls. All blood samples were tested for Complete Blood Count(CBC). Haemoglobin level were lower in 9% (9/100) patients and normal in 91% (91/100) patients. The mean of MCV and MCH were (105.20 ± 3.521, 34.50 ± 1.014) (P. value 0.001) increased in (hypothyroidism) patients, and (87.92 ± 1.21, 28.59 ± 1.856) (P. value 0.001) normal in(hyperthyroidism) patients. The mean of MCHC was 33.00 ± 1.078 (P. value 0.001) normal in (hypothyroidism) patients, and 31.67 ± 1.858 (P. value 0.001) normal in(hyperthyroidism) patients respectively). Nine percent showed an elevation in the mean cell volume (MCV) in the hypothyroidism patients. This increase was found correlated with the severity of the disease.