Abstract:
Macrocytic anemia can develop infrequently in patients with thyroid disease
mainly hypothyroidism and has high mortality rate. hypothyroidism –induced
Macrocytic anemia is a serious problem that affect patients treatment . The
objective of this study is the detection of changes in hematological
parameters (mean cell volume, mean cell hemoglobin) among Sudanese
patients with thyroid disease attending certain Khartoum clinical centers.
A descriptive cross – sectional hospital-based study was conducted from
(March 2013 to August 2013). 100 blood samples were taken from Sudanese
thyroid disease patients (59 patients were hyperthyroidism and 41 patients
were hypothyroidism) in police hospital and East Nile hospital and 50 blood
samples from healthy volunteers as controls. All blood samples were tested for
Complete Blood Count(CBC).
Haemoglobin level were lower in 9% (9/100) patients and normal in 91%
(91/100) patients. The mean of MCV and MCH were (105.20 ± 3.521, 34.50 ±
1.014) (P. value 0.001) increased in (hypothyroidism) patients, and (87.92 ±
1.21, 28.59 ± 1.856) (P. value 0.001) normal in(hyperthyroidism)
patients.
The mean of MCHC was 33.00 ± 1.078 (P. value 0.001) normal in
(hypothyroidism) patients, and 31.67 ± 1.858 (P. value 0.001) normal
in(hyperthyroidism) patients respectively).
Nine percent showed an elevation in the mean cell volume (MCV) in the
hypothyroidism patients. This increase was found correlated with the severity
of the disease.