Evaluation of Haemostatic Parameters Among Sudanese Pregnant Women In Khartoum State

Abstract

This is an analytical case-control study, conducted at national insurance fund (NSIF) health center in Khartoum city during the period from the March to August 2010. The aim of this study was to assess the haemostatic parameters (platelet, PT, INR and APTT) in Sudanese pregnant women in Khartoum who attend (NSIF). One hundred twenty five blood samples (125) were collected from hundred (100) Sudanese pregnant women, and twenty five (25) Sudanese non pregnant (control) .the study was conducted between March 2010 and August 2010 in Khartoum state. The participants were informed about the study and agreed for participation. The study population was divided into three groups according to the month of pregnancy first, second, and third trimester. Five ml of venous blood were taken from each subject, 2.5ml in EDTA containers, and 2.5 ml in tri sodium citrate containers these were tested for the platelet count, PT, and APTT. Fully automated haematological analyzer (Sysmex) was used for platelet count, PT, and APTT were analyzed manually. Statistical analysis showed significant decreased in platelet count mean during pregnancy (227.3100) compared with control (332.4000) P.value (0.000). Significant difference (p.value 0.025) was noted between the PTT mean of pregnant women (30.7300) and PTT mean of non pregnant women (32.5600). Also a significant decreased in PT mean of pregnancy (14.6900) compared to the control group (15.2800), with (P.value 0.044). There was mild deceased in INR mean during pregnancy (1.1871) compared to control (1.2400) but it was not significant (P.value 0.121).