Evaluation of Haemostatic Mechanism among Heart disease Patient Attending Khartoum North Teaching Hospital

Abstract

This is an analytical case-control study, conducted at Khartoum north Teaching Hospital during the period from January to June 2010. The aim of this study was Evaluation of some haemostatic parameters (platelet count, PT ,APTTand INR) in heart disease patients attended Khartoum north Teaching Hospital. Sixty patients with heart disease were informed about the study and agreed for participation. The study population was divided into three groups according to type of disease, 29 ischemic heart diseases, 19 heart failure, 12 Angina. Five ml of venous blood was taken2.5ml in EDTA containers and 2.5 ml in tri sodium citrate containers and investigated for the platelet count, PT, APTT and INR. Fully automated haematological analyzer Sysmex was used for platelet count, and automated coagulometer analysis for PT ,APTT and INR . All heart disrase patients had mean values of Platelet = 253.000cell/mm 3 normal compared with control value = 265.000 cell/mm3, PT=17.06second, prolong compared with control mean value = 14.5 second, P.value = 0.01. INR=1.4, increased compared with control mean value = 1.2, P.value = 0.007.APTT = 32.5second, normal compared with control mean value = 30.6, P.value = 0.65. The Reseach conclude that the heart disease affect the prothrombin time.