Estimation of Thyroid Hormones and TSH in Type 2 Diabetic Patients in Khartoum State

Abstract

This study was conducted to measure serum levels of thyroid hormones and TSH in patients with type2 diabetes mellitus. 50 samples were collected from patients in a period between February to March 2016, chosen randomly from Jabber Abo Aleiz hospital, and 25 apparently healthy individuals as control to assess the effect of diabetes mellitus on thyroid hormones (T3,T4) and (TSH) levels. Competitive Enzyme Immunoassay method was used to estimate serum thyroid hormones levels by using ELISA. Results were analyzed using statistical packageof social science (SPSS) computer program.The study results showed that serum level of T4 was significantly increased (p-value=0.000) in diabetic patients and the serum levels of T3 and TSH were insignificantly differences (p-value=0.229) (p-value=0.211) respectively. Mean ±SD for cases versus controls:(1.25±0.32 versus 1.16±0.25) for T3, (8.99±1.06 versus 7.59±1.23) for T4 and(1.96±0.80 versus 1.71±0.79) for TSH Also the mean of thyroid hormones levels were insignificantly increased in female patients compared to male patients. Mean ±SD for males versus females: (1.187±0.215 versus 1.272±0.405) for T3, (8.376±1.177 versus 8.769±1.464) for T4 and (1.686±0.771 versus 2.009±0.834) for TSH. Also this study showed that no correlation between T3 (r=.038, p-value=.792),T4 (r=.083, p-value=.568) and TSH (r=.063, p-value=.662) levels and duration of diabetes mellitus. It is concluded that the serum levels of T4 were significantly increased in the Sudanese patients with type2 diabetes mellitus and no differences in the levels of T3 and TSH. This place them at risk of developing thyroid diseases.