Early Neonate Sepsis: Hematological Changes and Risk Factors

Abstract

Neonatal sepsis is one of the important causes of neonatal morbidity and mortality particularly in the developing countries and its diagnosis remains challenging. This is a case control analytical study conducted in Omdurman Teaching Hospital , Khartoum State during the period ( April- July ) 2015.One hundred neonates confirmed as neonatal sepsis (case) and thirty healthy neonates ( control) of both sexes were enrolled inthe study. Venous blood was collected antiseptically from the neonates and analyzed by a hematological analyzer ( Sysmex KX2IN) .The obtained data was analyzed by SPSS version 20 .A significant positive correlation was found between maternal urinary tract infection (P ≤ 0.01) , miscarriage (P ≤ 0.00) and neonate sepsis .No correlation was found between neonate sepsis and prolonged membrane rupture (P ≤ 0.16) or route of delivery. C-section delivery (P ≤ 0.62) and spontaneous vaginal delivery (P ≤ 0.77) Septic neonates registeredsignificantlyhigher values ( P≤ 0.05) than the control group with regard to WBCs (17.4 vs9.3) ×109 /L , neutrophil (60.3% vs 47.9 %) and low platelets count (161.7 vs 202) ×109 /L . No significant changes ( P value ≤0.05) were observed between the septic neonates and the control group with regard to Hb ,RBCs Hct and red cell indices. It is concluded that early onset sepsis is manifested with significant changes in some hematological parameters.