Measured of Some Haematological Parameters Among Radiation and Benzene Station Workers - Khartoum State

Abstract

Radiation technicians are at risk of varying degrees of radiation exposure during their work and changes in hematological parameters and exposure to benzene depression of peripheral blood cells is a well-known indicator of benzene hematotoxicity. The aim of this study to evaluate radiation effect and benzene toxicity on haematological parameters and the results of the present study suggest that in radiation effect and toxicities of benzene depend on the time of exposure. This is a descriptive, cross sectional study to determine changes of some haematological parameters in radiation and benzene station workers, people recruited for this study were age (18-52 years), male and female Sudanese radiation and benzene station workers, duration of work range from 1-30 years ,these people work for 3 dayes/week to benzene equivalent to 18 hours/day and about 8 hours /day to radiation in Khartoum state. The study period extended from March 2014 to May 2014. This study was conducted using special questioner and taken 150 venous blood samples (50 radiation,50 benzene and 50 control) in EDTA containers, were taken to laboratory for investigation CBC for study subjects and healthy volunteers as controls, investigations were performed by using sysmex and manual thin blood film. Result show that CBC parameters of radiation workers there was significant difference between radiation workers and control on platelets count (Mean = 173±59),(P value=.000), thrompocytopenia increased when increased the number of years of work, while all CBC parameters of benzene workers significantly decreased in TWBCs(Mean = 3.4±.6)(P value = .00), RBCs (Mean = 3.4±.6)(.00), Hb (Mean = 12.5±.9)(P value =.00), HCT(Mean = 38±2)(P value =.00),MCV(Mean = 77±8)(P value =.00), MCH(Mean =27±9)(P value =.00),MCHC(Mean = 32±7), PLTs(Mean=125±32)(P value = .00), N(Mean = 54±11)(P value=.00), L(Mean = 37±9)(P value =.00), M(Mean =13±6)(P value = .00) when compared to correspondent parameters of the control subjects but with the exception in counts of eosinophil (Mean = 5±3)(P value =0.1) and basophil (Mean = .4±.6) (P value = 0.8) which were higher than that control ,and observed association between exposure to benzene and pancytopenia which increase by working duration. CBC parameter show that there was significant difference between radiation workers and control on platelets count, thrompocytopenia increased when increased the number of years of work and observed association between exposure to benzene and pancytopenia which increase by workin duration.