Complete Blood Count In Sudanese Breast Cancer Female Patients attending Radiation Therapy and Isotope Center of Khartoum (RICK( at Khartoum state

Abstract

This is a descriptive cross-sectional study conducted during the period from January 2010 to March 2010 in Radio isotopes center at Khartoum state (RICK), the study aims to determine complete blood count and reticulocyte count among 100 sudanese breast cancer female patients, as test group, and apparently healthy volunteer, as control group. The patients with an age range between26 --78year, with average value of 52 + 2 years, and the control group with age range between 27—55year, with average of 41+2. 72% of patients had been diagnosed with Invasive ductal carcinoma )IDC(,6% were Infiltrative Lobular Carcinoma)ILC(, 6% were muscular carcinoma,3% were Lymphatic Sarcoma ) LS(, 3%were Adenocarcinoma )AC(, 2% were fibrocystic carcinoma)FC),2%were inflammatory carcinoma)IC(,2%were mammory cell carcinoma)MCC(,2%were Papillary carcinoma)PC(,2% were Invasive Medolory carcinoma )IMC). There were 44% of patients in grade 11, 27% in grade 111, and 22% in grade 1V. Complete blood count was estimated by sysmex using cell pack for dilution Astromatolyzer for RBCs lyses. The results showed that all female patients had a history of breast cancer for about three month or more, also the results indicated that there were 30% of patients had a family history and 20% of them had a history of oral contraceptive use. 30% of patients were treated with mastectomy, 30% with chemotherapy and 40% with mastectomy, radiotherapy with chemotherapy. Accordingly the average value of CBC in female patients, HB, PCV, MCV, MCH, MCHC, PLTs were significantly decreased, whereas TWBCs and Reticulocyte count were in the limit of control values .In the test group, mean of Hb and PLTs were positively correlated with the dose frequency of chemotherapy, while the means of WBCs was not correlated with it, The mean of Hb, WBCs PLTs were decreased in patients who had a total mastectomy than who didn’t had. Also the mean of Hb, was highly decreased in patients who had been treated with mastectomy, radiotherapy and chemotherapy, while the mean of PLTs count was mildly decreased, put the mean of WBCs count was not affected by these group of treatments. Also the study showed that there were about 63% of patients suffering from anemia 36% had a normocytic hypochromic anemia and the other 27% had a microcytic hypochromic anemia. In this study the main cause of anemia in breast cancer was the intensive dose of chemotherapy.