Abstract:
This is a descriptive cross-sectional study conducted during
the period from January 2010 to March 2010 in Radio
isotopes center at Khartoum state (RICK), the study aims to
determine complete blood count and reticulocyte count
among 100 sudanese breast cancer female patients, as test
group, and apparently healthy volunteer, as control group.
The patients with an age range between26 --78year, with
average value of 52 + 2 years, and the control group with
age range between 27—55year, with average of 41+2.
72% of patients had been diagnosed with Invasive ductal
carcinoma )IDC(,6% were Infiltrative Lobular Carcinoma)ILC(,
6% were muscular carcinoma,3% were Lymphatic Sarcoma )
LS(, 3%were Adenocarcinoma )AC(, 2% were fibrocystic
carcinoma)FC),2%were inflammatory carcinoma)IC(,2%were
mammory cell carcinoma)MCC(,2%were Papillary
carcinoma)PC(,2% were Invasive Medolory carcinoma )IMC).
There were 44% of patients in grade 11, 27% in grade 111,
and 22% in grade 1V.
Complete blood count was estimated by sysmex using cell
pack for dilution
Astromatolyzer for RBCs lyses.
The results showed that all female patients had a history of
breast cancer for about three month or more, also the results
indicated that there were 30% of patients had a family
history and 20% of them had a history of oral contraceptive
use. 30% of patients were treated with mastectomy, 30%
with chemotherapy and 40% with mastectomy, radiotherapy
with chemotherapy.
Accordingly the average value of CBC in female patients, HB,
PCV, MCV, MCH, MCHC, PLTs were significantly decreased,
whereas TWBCs and Reticulocyte count were in the limit of
control values .In the test group, mean of Hb and PLTs were
positively correlated with the dose frequency of
chemotherapy, while the means of WBCs was not correlated
with it, The mean of Hb, WBCs PLTs were decreased in
patients who had a total mastectomy than who didn’t had.
Also the mean of Hb, was highly decreased in patients who
had been treated with mastectomy, radiotherapy and
chemotherapy, while the mean of PLTs count was mildly
decreased, put the mean of WBCs count was not affected by
these group of treatments.
Also the study showed that there were about 63% of
patients suffering from anemia 36% had a normocytic
hypochromic anemia and the other 27% had a microcytic
hypochromic anemia.
In this study the main cause of anemia in breast cancer was
the intensive dose of chemotherapy.
