Abstract:
This is a descriptive study conducted in El Nou Hospital (Screening Center
for Cervical Cancer )during the period from December 2009 to August aghast
2010. The study aimed to find out if there is any relation between HPV16
and18 in cervical cancer and oral epithelial cells infection.
HPV was
investigated among 50 women of whom, 40 were patients with cervical
lesions and 10 were clinically healthy (as control group). For each study
subjects two specimens were taken (cervical cells and oral cells). The DNA
was extracted from tissue samples then polymerase Chain Reaction (PCR)
was applied to investigate the HPV. In this study, among 40 patients with
cervical lesions, HPV was identified in sixteen (40%) of study subjects. Of the
eight (20%) positive with HPV subtype 16, six (15%) were identified with HPV
subtype 18, and two (5%) were detected with both HPV subtypes 16 and 18.
All of the clinically healthy cases were found negative.
However, in specimen from oral cavity only one (2.5%) case was found
positive for HPV subtype 16.
HPV plays a critical role in the development of cervical cancer, in the
Sudan. No clear relation between cervical and oral HPV infection. The study
recommended screening more patients who suffer from cervical cancer using
more advanced molecular techniques to confirm the role of the HPV in
developing of cervical SCC in Sudan.
