Measurement of Lipid Profile among Renal Transplanted Patients in Gezira State 2013

Abstract

This study was conducted in Wad Madani Teaching Hospital in Gezira State during the period from April to August 2013. Objective: the main aim of the study is to assess the lipid profile among Renal Transplanted Sudanese Patients under Immunosuppressant treatment in Gezira State. Materials and methods: Eighty plasma samples were collected from renal transplanted patients under immunosuppressant treatment. The test group was divided into two groups according to the type of immunosuppressant drug , cyclosporine 30 subjects and tacrolimus 50 subjects) from both sexes at different age .In addition to 50 plasma sample from healthy people from both sexes at different age for comparison of total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein level. The level of lipid profiles in the study was estimated by enzymatic method using spectrophotometer. Results: the study showed significant increase in total cholesterol, triglyceride and low density lipoprotein level in renal transplanted patients when compared with control group. (157.3 ± 8.5 versus 124.2± 12.3 mg/dl, 152.2± 7.5 versus 92.7± 9.5 mg/dl, 61.2± 8.3 versus 50 ± 5.0 respectively), (p ≤0.05), with significant decrease in high density lipoprotein (34.3 ± 4.5versus 42.4.± 4.1), (p ≤ 0.05). In contrast triglyceride, total cholesterol, and LDL-cholesterol is significantly increased in transplanted patients treated with cyclosporine when compared with treated with tacrolimus (157.2 ± 14.6 versus 139.3 ± 13.1 mg/dl, 172.6± 11.4 mg/dl versus 153.9± 12.4 mg/dl, 68.0 ± 8.2 mg/dl versus 59.7±8.3 mg/dl respectively), (p ≤0.05), with significant decrease in HDL- cholesterol level in transplanted patients treated with cyclosporine when compared with treated with tacrolimus (30.7 ± 4.3 versus 36.5 ± 5.4 mg/dl )(p ≤0.05).The study recorded insignificance correlation between lipid profile and both age and the duration of the treatment in transplanted patients treated with both cyclosporine and tacrolimus (p ≥ 0.05). Conclusion: the study revealed significant increase in triglyceride, total cholesterol, and LDL-cholesterol, with significant decrease in HDL-cholesterol level in transplanted patients under immunosuppressant treatment, which is aggravated in patients treated with cyclosporine than treated with tacrolimus.