Abstract:
The aim of this study was to estimate the lipid profile among forty
five immunosupprresive kidney transplanted Sudanese patients
under Tacrolimus as immunosuppression drug, the mean age was
35.33+1.1 years and duration of transplantation was 3.43+1.7
years. Thirty five apparently healthy individuals matched age and
sex, were involved as control group.
Serum total cholesterol (TC), triglyceride (TG), high density
lipoprotein- cholesterol (HDL-C) and low density lipoprotein-
cholesterol (LDL-C) were estimated by using Biosystem kits
(enzymatic methods) and spectrophotometer (T70, Germany).
Renal allograft recipients showed significantly high levels in serum
cholesterol, triglyceride, low density lipoprotein- cholesterol
(p=
0.023, 0.00, 0.00) respectively, and insignificant difference for
HDL-C (p= 0.735) compared with normal control.
Also there were significant increase levels in serum cholesterol,
triglyceride, low density lipoprotein- cholesterol and high density
lipoprotein- cholesterol and duration, and there was insignificant
between lipid profile and sex.
The finding in this study confirmed that the immunosuppressant
drug increase the plasma levels of lipid profile and Tacrolimus has fewer unfavorable effects on lipid profile when compared with
.cyclosporine A
