Evaluation of serum Prolactin level in Breast Cancer patients in Khartoum state

Abstract

A descriptive cross-sectional study was conducted to evaluate Prolactin level in women with breast cancer, and to correlate serum Prolactin level with risks factors of breast cancer. The study included, fifty patients histopathologicaly diagnosed with breast cancer and forty healthy individuals as control group, the study was carried out in Radio Isotope Centre Khartoum (RICK), during the period from April to December 2013. Serum prolactin level in both patients and control group was estimated using Micro-practical Enzyme Immunoassay technology (MEIA), data analyzed using t-test and Pearson correlation in SPSS computer program. The results showed that serum prolactin level is significantly increased in patients versus Controls with (P-value 0.001), also the results showed significant increase in the mean serum prolactin level among patients with breast cancer >40 years (postmenopausal) compared with <40 years (premenopausal) with (P-value 0.003). The study concluded that Serum PRL levels were higher in women with breast cancer than the controls, prolactin level positively correlated with age, stage of the disease and there was no correlation with the family history.