Evaluation of Haemostatic Parameters and Hemoglobin Concentration in Sudanese Breast Cancer Women Patients in Radiation Therapy and Isotope Center in Khartoum

Abstract

This is a descriptive cross-sectional study conducted during the period from March 2011 to June 2011 in Radio isotopes center(RICK) at Khartoum state , the study aimed to determine the coagulation mechanism among 100 Sudanese breast cancer female patients, as test group, and 50 healthy female , as control group. The patients with an age range between 31-70 year, with average of 49 years, and the control group with age range between30 -70 year, with average of 47 years. Five (5) ml of venous blood were collected from breast cancer female patients and control group, 3 ml were added in trisodium citrate anticoagulant to preparation of platelet poor plasma from citrated blood by centerfuogation at 3000 round /minute for 15minute, the ppp analyzed by using coagulometer instrument (clot) for PT and APTT, the reaming 2 ml of blood was added in EDTA antcoagulated for platelet count and Hemoglobin measurement by using automated hematology analyzer (F-820). Fifty one percent of patients had been diagnosed with Invasive ductal carcinoma (IDC), 27% were ductal carcinoma (DC) ,5% were Invasive cystic carcinoma (ICC) ,4% were Bilateral carcinoma (BC), 4% were inflammatory breast cancer (IC), 3% were Lobular carcinoma (LC), 3% were Papillary carcinoma (PC) and 3% with Phyllodes tumor(PsT). There were 45% of patients in grade 11, 25 % in grade 1, 21% in grade 111 and 5% in grade 1Vand 4% grade Zero. The results showed that all females patients had a history of breast cancer for about several months, also the results indicated that there were79% of patients had been treated with chemotherapy, 3% treated with chemo/radiotherapy and remaining not treated with any types of treatment . Also the result showed that Hb and platelets were in the limit of control values. PT and INR were significantly increased and APTT were decreased according to control group. The result indicate that the mean of PT &INR increased in patients with invasive ductal carcinoma and phyllodes tumor ,when the mean of APTT increased in patient with phyllodes tumor, the means of Hb and platelet were decreased in papillary carcinoma and phyllodes tumor .Also the result indicated the mean of PT and INR increased in patient had not treated and patient treated by chemotherapy ,when the mean of APTT decreased in patient treated with chemo/radiotherapy ,with no correlate between this parameters and dose of treatment. The conclusion of this study proved that the mean of PT increased in breast cancer patient female probably due to defect in the liver function or decreased the level of vitamin K Also the decreased in APTT which probably result of circulating activating clotting factors and elevated level of factor VIII.