Abstract:
This is a descriptive cross-sectional study conducted during the
period from March 2011 to June 2011 in Radio isotopes center(RICK) at
Khartoum state , the study aimed to determine the coagulation
mechanism among 100 Sudanese breast cancer female patients, as
test group, and 50 healthy female , as control group. The patients with
an age range between 31-70 year, with average of 49 years, and the
control group with age range between30 -70 year, with average of 47
years.
Five (5) ml of venous blood were collected from breast cancer female patients and
control group, 3 ml were added in trisodium citrate anticoagulant to preparation of
platelet poor plasma from citrated blood by centerfuogation at 3000 round /minute for
15minute, the ppp analyzed by using coagulometer instrument (clot) for PT and APTT,
the reaming 2 ml of blood was added in EDTA antcoagulated for platelet count and
Hemoglobin measurement by using automated hematology analyzer (F-820).
Fifty one percent of patients had been diagnosed with Invasive ductal
carcinoma (IDC), 27% were ductal carcinoma (DC) ,5% were Invasive
cystic carcinoma (ICC) ,4% were Bilateral carcinoma (BC), 4% were
inflammatory breast cancer (IC), 3% were Lobular carcinoma (LC), 3%
were Papillary carcinoma (PC) and 3% with Phyllodes tumor(PsT).
There were 45% of patients in grade 11, 25 % in grade 1, 21% in
grade 111 and 5% in grade 1Vand 4% grade Zero.
The results showed that all females patients had a history of breast
cancer for about several months, also the results indicated that there
were79% of patients had been treated with chemotherapy, 3% treated
with chemo/radiotherapy and remaining not treated with any types of
treatment .
Also the result showed that Hb and platelets were in the limit of control
values. PT and INR were significantly increased and APTT were
decreased according to control group. The result indicate that the
mean of PT &INR increased in patients with invasive ductal carcinoma
and phyllodes tumor ,when the mean of APTT increased in patient with
phyllodes tumor, the means of Hb and platelet were decreased in
papillary carcinoma and phyllodes tumor .Also the result indicated the
mean of PT and INR increased in patient had not treated and patient
treated by chemotherapy ,when the mean of APTT decreased in patient
treated with chemo/radiotherapy ,with no correlate between this
parameters and dose of treatment.
The conclusion of this study proved that the mean of PT increased in
breast cancer patient female probably due to defect in the liver
function or decreased the level of vitamin K
Also the decreased in APTT which probably result of circulating
activating clotting factors and elevated level of factor VIII.
