Assessment Of Serum Total Cholesterol Level and Aspartate Transaminase Activity Among Sudanese Cigarette Smokers (Study in Khartoum State

Abstract

This study was carried out to measure serum total cholesterol level and Aspartate transaminase (AST)activity in the blood male of Sudanese with cigarette smokers. Fifty samples were collected from cigarette smokers without any disease in period between May –September 2013. Fifty smokers between the age 18-86 years and with duration ranging 2-35years .two and half of blood samples were taken from these cigarette smoker’s as well as 50 male non smokers also in this study roll all the participant were randomly select present social status. Samples were collected from non cigarette smoker’s subject as control group to measure serum total cholesterol level by using colorimeter and Aspartate transaminase (AST) activity By using sepectrophotometer All results were analyzed using statistical of package social science ) SPSS( computer program. The study showed that a significant elevation of serum total cholesterol level in cigarette smokers (211±8.3) mg/dl when compared to non cigarette smokers (154+5.4) mg/dl with P.value (0.008) The study also showed that Aspartate transaminase (AST)activity was significant ly increased in blood of smokers compared to control being (38±10) μ/l (23±5.4) μ/l with P.value (0.001) . The study indicates that the duration of cigarette smokers significantly increased has the level of cholesterol and Aspartate transaminase(AST) activity with p.value (0.007) . The study indicates that the number of cigarette /day has significant difference between serum total cholesterol level. Mean 2-10 cigarette/day (209±5.7) mg/dl more than 11cigarette /day (224±8.4) mg/dl p.value =0.0000 The study indicates that serum total cholesterol level is not significantly affected by age of cigarette smokers there is no different in value in total cholesterol level between two age group in this study Mean in 18- 45 years (211±5.5) mg/dl 46- 85years (209±4.1) mg/dl with p.value (0.34) . The enzyme Asparate transaminase (AST)activity was no significant differ the value was regret to duration of smoker age the smoker number cigarette smokers. Person correlation show correlation that there was significant weak positive between the duration of cigarette smokers and the level of Serum cholesterol and r = 0.065 with p.value (0.65) no significant between duration and total cholesterol level cigarette smokers also no correlation between age of smokers number of smoker . Aspartate transaminase activity in other hand also show no correlation of statistical significance with duration of smoker ,age smoked and number of smokers the out came of this study total cholesterol level and Aspartate transaminase (AST)activity enzyme significance increase in blood of the smokers with remarkable affect duration of smoker and number of cigarette smoked. Condition that may increase the risk of cardiovascular disease and atherosclerosis.