Abstract:
This is a descriptive cross sectional study which was
conducted in Khartoum state during the period from April/
2013 to July / 2013 to evaluate the effect of type 2
diabetes on coagulation tests (Prothrombin time, Activated
partial thrompoblastin time, Thrombin time and Fibrinogen
level). A 100 sample were collected from type 2 diabetic
patient according to inclusion criteria and considered as
case, and 50 samples were collected from healthy
individual and considered as control.4.5 ml of fresh venous
blood where collected from diabetic patient , after filling
the questionnaire, in plastic container containing 0.5ml of
3.2 % tri sodium citrate solution for anticoagulation . Then
the contents of the container were mixed and centrifuged
at 3000 round / min for 15 minutes for preparation of
platelets poor plasma (ppp).the ppp were tested for the
Prothrombin time, Activated partial thrompoblastin time,
Thrombin time and fibrinogen level by using the
coagulometer. The results were analyzed by independent
T test the SPSS computer programme. The result of cases
revealed that Prothrombin time =14.1seconds , Activated
partial thrompoblastin time=31.6 seconds , ,Thrombin
time=5.8
seconds and fibrinogen=572.5 mg/dl . The
results of control group revealed that Prothrombin
time=13.2 seconds .Activated partial thrompoblastin time
=29.4 seconds, Thrombin time= 7.8
seconds and
fibrinogen level= 274.0 mg/dl.
Over all the results were showed significant increase in
PT , PTT and Fibrinogen level when compared with control
group with P value > 0.00 (This increase within normal
range), and significant decreased in TT when compared
with control group with P value > 0.00. no significant
change noticed in the different sex in APTT,TT and
Fibrinogen with P value >0.05 but there was significant
change noticed in the different sex in PT with p
value<0.05.no significant change noticed in the different
age group in PTT ,TT and Fibrinogen with P value >0.05
-
but there was significant change noticed in the different
age group in PT with p value<0.05.
