Prevelance of Polymorphism at the 5' Promoter Region Of CYP3A5 Gene In Acute Lymphoblastic Leukemia Patients In Gaza Strip

Abstract

A laboratory based descriptive and analytical study was carried out in Gaza stripe Palestine 2004-2005. The aim of this study is to identify the .prevelance of polymorphism at the 5' promoter region of CYP3A5 genes The distribution and risk factors of leukemia disease among children less than 15 years, and to assess the association between certain laboratory results and the security and prognosis of disease . Data was collected through structured questionnaire administrated to 40 subjects parents. Response rate was 95%. The incidence rate of Leukemia disease was 66.2% according to governorate. Clear variations were found in incidence according to sex, age groups, governorate and socio- demographic and economic status. The disease was prominent among .(children less than 16 years with percentage (5% The risk age group was children less than 15 years (95%). Males less than 10 years lived in Gaza governorate were more likely to have Leukemic disease than Females. Low socio-encomic status, families' index, parents of low educational level and with low income jobs were not associated with the disease, and its severity. Leukemia was not associated with the CYP3A5 polymorphism and the study showed that there are association between CYP3A5 and the count of some type of leukocytes such as Neutrophiles and Eosinphiles and in the other hand there is no association between CYP3A5 and other type of leukocytes such as lymphocytes, Monocytes, Basophiles, and the study finding there is no association between lymphocytes count but there is association lymphoblast cells and CYP3A5 gene the study recommended the need for conducting further studies and researches about the major risk factors associated with Leukemia, and preterm labor in relation to Leukemia in Gaza strip and West Bank, conducting the further studies are required to evaluate the quality of Leukemia patients in all different health organizations and the clients perception and satisfaction towards the .services of this care