Association between Iron Profile and Hepatitis B Viral Load in Sudanese Patients

Abstract

Hepatitis B Virus infection is a major global public health problem , Chronic hepatitis B virus (HBV) infection affects 240 million people worldwide and can lead to chronic liver diseases including chronic hepatitis B (CHB), cirrhosis, and hepatocellular carcinoma (HCC).This is case control study carried out in Khartoum state in Elriyada medical laboratory aimed to associate the iron profile with chronic hepatitis B viral load , in the period from April to June 2019.Sixty samples were collected from patients with HBV infection and sixty samples were collected from healthy individuals. Serum samples were separated from participants for estimation of iron, ferritin , transferrin ,TIBC , ALT and viral load , (DIRUI CST 240) automated chemistry analyzer used for iron ,TIBC, transferrin and ALT , while ferritin was estimated using( TOSOH AIA1800) ,results of viral load was collected from data recorded from Real Time PCR, data was analyzed by SPSS version 23. the mean of serum iron was significant lower in cases group (86.3±36) when compared with control group(129 ±49) the mean of TIBC were significant lower in study group(212.6±56) when compared with control group(374±46),in addition ;the mean of ferritin is also significantly high in cases group(241.6±161) when compared with controls group(86.6±13),no significant difference in transferrin between case and control. When comparing the iron profile in case group between different viral load found that significantly decreased in mean of serum iron in patients with high viral load(82±26) when compared with low(87 ±43)and very low (98±23) also there is significant decreased in mean of TIBC in patient with high viral load(193±35) when compared with low(205±45) and very low (223±65) .ferritin level was increased in high viral load (212±54)when comparing with low(198±54) and very low(161±61) viral load ranges. Also significant negative correlation was found between ALT and viral load level (-.515), Iron metabolism disorders can occur in patients with HBV infection. The serum markers of iron metabolism disorders vary in different level of HBV-activity levels.