Abstract:
Hepatitis B Virus infection is a major global public health problem , Chronic hepatitis B virus
(HBV) infection affects 240 million people worldwide and can lead to chronic liver diseases
including chronic hepatitis B (CHB), cirrhosis, and hepatocellular carcinoma (HCC).This is case
control study carried out in Khartoum state in Elriyada medical laboratory aimed to associate the
iron profile with chronic hepatitis B viral load , in the period from April to June 2019.Sixty samples
were collected from patients with HBV infection and sixty samples were collected from healthy
individuals. Serum samples were separated from participants for estimation of iron, ferritin ,
transferrin ,TIBC , ALT and viral load , (DIRUI CST 240) automated chemistry analyzer used for
iron ,TIBC, transferrin and ALT , while ferritin was estimated using( TOSOH AIA1800) ,results
of viral load was collected from data recorded from Real Time PCR, data was analyzed by SPSS
version 23. the mean of serum iron was significant lower in cases group (86.3±36) when compared
with control group(129 ±49) the mean of TIBC were significant lower in study group(212.6±56)
when compared with control group(374±46),in addition ;the mean of ferritin is also significantly
high in cases group(241.6±161) when compared with controls group(86.6±13),no significant
difference in transferrin between case and control. When comparing the iron profile in case group
between different viral load found that significantly decreased in mean of serum iron in patients
with high viral load(82±26) when compared with low(87 ±43)and very low (98±23) also there is
significant decreased in mean of TIBC in patient with high viral load(193±35) when compared
with low(205±45) and very low (223±65) .ferritin level was increased in high viral load
(212±54)when comparing with low(198±54) and very low(161±61) viral load ranges. Also
significant negative correlation was found between ALT and viral load level (-.515), Iron
metabolism disorders can occur in patients with HBV infection. The serum markers of iron
metabolism disorders vary in different level of HBV-activity levels.
