Estimation of Prpthrombin and Activated Prothrombin Time among Sudanese Patients Taking Antipsychotic Drugs in Khartoum State

Abstract

This case control study aimed to evaluate of Prothrombin Time, International Normalized Ratio and Activated Partial Thromboplastin Time among patients taking antipsychotic drugs in Al-Tigany Al-Mahy Mental Health Hospital in Khartoum state at the period from March to November 2019. Two hundred subjects were included and selected randomly, they were grouped into case group (n=100) who were psychiatric patients and the apparently healthy group were control group (n=100). Both, age and sex are matched. Venous blood sample (1.8ml) was collected in 3.2% tri sodium citrate container. Then, plasma was separated by centrifugation for 15 minutes, evaluation of coagulation profile ( PT, INR and APTT) by using coagulometer device. The data was analyzed using SPSS program (Version 20) using independent T-test and one way ANOVA for testing significance and frequencies, mean and SD, p.value significant ≤ 0.05. The Mean and SD of PT in male and female of the case group was 17.7 ± .5 and 19.3 ± .4 respectively and in control group was 13.7 ±1.2 in male and 13.4 ± 1.4 in female with significant statistical correlation p.value 0.00. The Mean and SD of PTT in male and female of case group was 35.6 ±1.4 and 37.2 ± 1.1 respectively and in control group was 31.6±2.4 in male and 31.4±2.6 in female with significant statistical correlation p. value 0.00 The Mean and SD of INR in male and female of case group was 1.4± 0.04 and 1.5±0.04 respectively and in control group was 1.2 ± 1.3 in male and 1.3 ± 1.4 in female respectively with no statistical correlation p. value 0.13 There was statistical correlation between gender and PT, APTT and INR (P. value 0.00).