Abstract:
Nine new substituted mefenamic acid derivatives were synthesized by the reaction
between the amino group in mefenamic acid and acyl chloride to give tertiary
amine and reaction of free carboxylic acid of mefenamic acid with alcohol to give
ester, ACD/Lab program method for Moleculardesign was described. The results
on application of ACD/Lab program in calculation and correlation of structure
properties of the some mefenamic acid derivatives reported. The synthetic design
of these compounds was achieved through retrosynthetic analysis (RSA) approach.
The reaction progress for all synthesized compounds was checked by (TLC) and
m.p. techniques, and the structures of the synthesized compounds were confirmed
using IR, 1HNMR, UV, and GC-MS.
