Abstract:
This is a quantitative, descriptive, cross sectional study was conducted during the
period from September to December, 2014. The objective of study was to assess
the efficiency of HBV vaccine in Health Care Workers in some hospitals in
Khartoum State.
A total of eighty nine Hepatitis B vaccinated participants (n=89) were enrolled
in this study. The participants, were screened before taking the vaccine and have
no history of infection by Hepatitis B or other jaundice, all participants were
vaccinated with three doses. The period ranges from 6 month to 10 years after
last dose. All samples were screened by Immune Chromatography Test (ICT) to
detect HBsAg. The titer of Anti-Hepatitis B antibody was estimated using
Enzyme Linked Immune Sorbent Assay (ELISA).
The number of participants were28 (31.5%) males, and 61(68.5%) females.
The positive anti-HBsAg females were 45, while the positive males to
antiHBsAg were 21.
Smokers positive to anti-HBsAg ware 8, smoker negative to anti-HBsAg were 3,
58 of no smoker gave positive result.20of no smoker negative result. The
efficiency of the vaccine varied from one group to another. The participants ;
were groped-according to age as follow. 20-30 years (54) effective (41),and not
effective(13),31-40years 26, effective(18)and not effective(8),41-50years 4,
effective(4)and not effective(0), 51-60 years 3,effective(2) and not effective(1),
61-70 years2 effective(1)and not effective(1).
The participants were also grouped according to the last dose of taken as
follows: 6-20 month positive anti-HBsAg 26, negative anti-HBsAg3,
2135month positive anti-HBsAg 12, negative anti-HBsAg7 , 36-50 month
positive anti-HBsAg 9, negative anti-HBsAg6, 51-65 month positive antiHBsAg
7, negative anti-HBsAg1, 66-80 month positive anti-HBsAg 3, negative anti-
HBsAg0,81-95 month positive anti-HBsAg 1, negative antiHBsAg2, 96-110 month positive anti-HBsAg 4, negative anti-HBsAg2, and 111-125 month
positive anti-HBsAg 4, negative anti-HBsAg2.
The efficiency of vaccine was observed 66(74.2%) and not effective in
23(25.8%).
The study concluded HBV rDNA vaccine was found to offer good
seroprotection and was highly immunogenic in Health Care Workers. Further
studies are required to validate results of this present study.
